SAM competitive inhibitor of EZH2
Protein target names: EZH2
Mechanism of action: SAM competitive inhibitor
In Vitro Validations
DOI Reference: 10.1021/ml3003346
In Cell Validations
In Vivo Data
No in Vivo Validations
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SERP ratings and comments
(last updated: 17 May 2016 )
GSK343 is an excellent potent and selective EZH2 probe suitable for cell culture. Use in animals is limited due to it being PgP substrate.
(last updated: 18 May 2016 )
The IC50 is ~300 nM for reduction of H3K37me3 in HCC1806 cells. Use GSK343 in parallel with UNC1999 as an orthogonal probe.
(last updated: 30 May 2016 )