GNE-9822

Inhibitor of ITK

Probe GNE-9822 is in the process of SERP review.

Please continue to check back for new reviews and commentary.

Probe Availability:

Uniprot ID: Q08881

Target Class: Kinase

Target SubClass: TK

Potency: Ki

Potency Value: 0.7 nM

Potency Assay: Biochemical Assay

PDB ID for probe-target interaction (3D structure): 4PQN

Structure-activity relationship: yes

Target aliases:

Tyrosine-protein kinase ITK/TSK, LYK, EMT, ITK, IT ...

Potency end-point : Ki Aurora A

Potency assay (off target): Aurora A Biochemical Assay

Probe Selectivity in Vitro:

Broad kinase selectivity of this molecule was observed: only six of 286 off-target kinases were inhibited >70% when tested at 0.1 μM (>100X ITK Ki).

No SERP comments found for GNE-9822