GLPG0974

Antagonist of FFAR2

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

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Probe GLPG0974 is in the process of SERP review.

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Information

FFAR2

Antagonist

up to 100 nM

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Probe Availability:

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Cell:

Within Target family: The close receptor homologue FFA3 (also called GPR41) is not inhibited by GLPG0974 up to 30 μM. Outside Target Family: Less than 50% inhibition at 10 μM was observed against all the 55 receptors, ion channels, and transporters from the Cerep ExpresSProfile. No inhibition of CYP450 isoforms was observed, and no time-dependent inhibition of CYP3A4 was noted. No inhibition of the hERG channel.

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SERP Ratings

In Cell Rating

In Model Organisms

(last updated: 5 Aug 2021 )