GDC-0834
GDC-0834 : ATP competitive inhibitor of BTK
Structure
In Cells
In Model Organisms
SERP ratings and comments
SERP Ratings
SERP Comments:
This compound was shown to be a substrate and inhibitor of human aldehyde oxidase. It is a good tool compound to use in cells and small animals, but there are marketed BTK inhibitors that would be more appropriate for routine experiments because they do not interact with AO.
(last updated: 2 Jun 2021 )
SERP Ratings
SERP Comments:
At higher concentrations (3-10 uM) this compound has off-target activities in human primary cell assays that may confound interpretation of results in phenotypic assays or animal studies. These activities include inhibition of proliferation of human primary endothelial cells, T cells, coronary artery smooth muscle cells and fibroblasts.
(last updated: 22 Jun 2021 )
SERP Ratings
(last updated: 13 Jul 2021 )