FAH65E(-)

FAH65E(-) : Inhibitor of BACE1

Structure

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Information

BACE1

Inhibitor

up to 1 uM

In Vitro Validations

Uniprot ID: P56817

Target Class: Enzyme

Target SubClass: Peptidase

Potency: IC50

Potency Value: 5 nM

Potency Assay: P5-P5′ assay

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Beta-secretase 1, KIAA1149, BACE, BACE1, BACE1_HUM ...

DOI Reference: 10.1016/j.neurot.2025.e00610

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): FAH65 was found to be selective for BACE1 as the target enzyme. FAH65 did not significantly inhibited cathepsin D (Cat D) activity, and BACE2 activity compared to BACE-IV. The FAH65 IC50 for Cat D, BACE2, and BACE1 are ∼47 μM, >1 μM and ∼0.01 μM, respectively.

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