Ezeprogind

Ezeprogind : Modulator of GRN

Structure

SERP Rating

In Cells

(2 ratings)

In Model Organisms

(2 ratings)

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Probe Ezeprogind is in the process of SERP review.

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Information

Modulator

100 nM, up to 1 uM
Reviewer recommended concentration: 100 nM

Probe Availability:

Mcule

In Vitro Validations

Uniprot ID: P28799

Target Class: Glycoprotein

Target SubClass: Granulin family

Potency: Kd

Potency Value: 201 nM

Potency Assay: Ability of AZP2006 to bind PGRN/PSAP complex by Fluorescent MST competition assay.

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Progranulin, GRN, GRN_HUMAN, PEPI, PCDGF, Glycopro ...

DOI Reference: 10.1038/s41598-021-94708-1

In Cell Validations

In Vivo Data

I have extra information to add

SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

(last updated: 13 Mar 2024 )

SERP Ratings

In Cell Rating

In Model Organisms

SERP Comments:

In the original publication the authors state: "Given the multiple actions of AZP2006, more experiments are needed to clearly understand the mechanism underpinning PGRN release and TLR9 inhibition. In particular, it would be interesting to better identify the mechanism used by AZP2006 to enter the cell and to target the lysosomes." Thus, AZP2006 can only be used with caution as a chemical probe for progranulin, a validated target of the molecule.

(last updated: 27 May 2024 )