Ervogastat |
Ervogastat : Inhibitor of DGAT2
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary
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| Targets | Biochemical/Biophysical Potency | Cellular Potency |
|---|---|---|
| DGAT2 |
|
|
up to 100 nM
Selectivity
In Vitro Selectivity Assessment
Potency Assay Off-Target:
Mouse MGAT1, human MGAT2, human MGAT3, or human DGAT1 potency IC50 > 50 μM
Functional assay from Inv ...
Potency Cellular
In Vitro
DGAT2
Mode of Action: Inhibitor
Structure-Activity-Relationship data available? Yes
DOI Reference: 10.1021/acs.jmedchem.2c01200
In Vivo Validations
Rat
Dose: 1 mg/Kg
Route of delivery:
Intravenous
Plasma half life:
0.3 h
Systemic clearance:
61 mL/min/kg
Volume of Distribution at Steady-State:
0.9 L/Kg
DOI Reference: 10.1021/acs.jmedchem.2c01200
Dose: 5 mg/Kg
Route of delivery:
Oral
Plasma half life:
1 h
Bioavailability:
31 %
DOI Reference: 10.1021/acs.jmedchem.2c01200
Monkey (Cynomolgus)
Dose: 1 mg/Kg
Route of delivery:
Intravenous
Plasma half life:
1 h
Systemic clearance:
10 mL/min/kg
Volume of Distribution at Steady-State:
0.7 L/Kg
DOI Reference: 10.1021/acs.jmedchem.2c01200
Dose: 5 mg/Kg
Route of delivery:
Oral
Plasma half life:
4 h
Bioavailability:
48%
DOI Reference: 10.1021/acs.jmedchem.2c01200
Chemical Information
| Molecular Formula | C21H21N5O4 |
| SMILEs | CCOc1cccnc1Oc1cncc(-c2ncc(C(=O)N[C@H]3CCOC3)cn2)c1 |
| InChI | InChI=1S/C21H21N5O4/c1-2-29-18-4-3-6-23-21(18)30-17-8-14(9-22-12-17)19-24-10-15(11-25-19)20(27)26-16-5-7-28-13-16/h3-4,6,8-12,16H,2,5,7,13H2,1H3,(H,26,27)/t16-/m0/s1 |
| Molecular weight | 407.16 Da |
| AlogP | 2.6433 |
| HBond acceptors | 9 |
| HBond donors | 1 |
| Atoms | 51 |
References
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