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DDD85646

Inhibitor of NMT1, NMT2

Structure

Information

  • NMT1
  • NMT2
  • Inhibitor
  • up to 100 nM

In Vitro Validations

Uniprot ID: P30419
Target Class: Other post-translational modification
Target SubClass: Acyltransferase
Potency: IC 50
Potency Value: 3 nM
Potency Assay: NMT enzyme assay 2 nM TbNMT, 2 nM LmNMT, 3 nM TcNMT;
PDB ID for probe-target interaction (3D structure): 2WSA
Structure-activity relationship: yes
Target aliases:
Glycylpeptide N-tetradecanoyltransferase 1, NMT, N ...

DOI Reference: 10.1038/nature08893

Uniprot ID: P30419
Target Class: Other post-translational modification
Target SubClass: Acyltransferase
Potency: Kd
Potency Value: 14 nM
Potency Assay: SPR (1 nM TbNMT)
PDB ID for probe-target interaction (3D structure): --
Target aliases:
Glycylpeptide N-tetradecanoyltransferase 1, NMT, N ...

DOI Reference: 10.1038/nature08893

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:
Not selective across species in vitro (biochemical assay)
Probe Selectivity in Cell:
DDD85646 shows promising selectivity at the cellular level
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SERP ratings and comments

No SERP comments found for DDD85646