DAPORINAD

DAPORINAD : Inhibitor of NAMPT

Probe DAPORINAD is in the process of SERP review.

Please continue to check back for new reviews and commentary.

Probe Availability:

Uniprot ID: P43490

Target Class: Enzyme

Target SubClass: Nicotinamide phosphoribosyltransferase

Potency: Ki

Potency Value: 0.3 nM

Potency Assay: Competitive binding assay using K-562 cell extracts ; non-competitive inhibition

PDB ID for probe-target interaction (3D structure): 2GVJ, 4O1B, 4O1D, 2G97

Target aliases:

Nicotinamide phosphoribosyltransferase, PBEF1, PBE ...

PMID Reference: 14612543

Probe Selectivity in Cell:

Clonogenic Assay in a Selection of Cancer Cell Lines shows little selectivity for DAPORINAD DOI: 10.1021/jm4009949

No SERP comments found for DAPORINAD