CPI-0610

Antagonist, Reversible, competitive inhibitor of BRD2, BRD4, BRD3, BRDT

Structure

Information

Protein target names: BRD2, BRD4, BRD3, BRDT

Mechanism of action: Antagonist, Reversible, competitive inhibitor

Recommended in-cell concentration:
10-500 nM

In Vitro Validations

Uniprot ID: P25440
Target Class: Epigenetic
Target SubClass: Bromodomain
Potency: IC50
Potency Value: 160 nM BD1, 25 nM BD2
Potency Assay: Alphalisa assay
PDB ID for probe-target interaction (3D structure): --
Structure-activity relationship: Yes, see J Med Chem paper
Target aliases:
Bromodomain-containing protein 2, RING3, KIAA9001, ...

DOI Reference: 10.1021/acs.jmedchem.5b0188

In Cell Validations

In Vivo Data

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(last updated: 19 May 2017 )

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(last updated: 22 May 2017 )

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(last updated: 13 Jul 2017 )