CM11 : Degrader (PROTAC) of VHL

Structure

Information

Protein target names: VHL

Mechanism of action: Degrader (PROTAC)

Recommended in-cell concentration:
10-500 nM

In Vitro Validations

Uniprot ID: P40337
Target Class: Other post-translational modification
Target SubClass: E3 ubiquitin ligase
Potency: Kd
Potency Value: 10 nM
Potency Assay: ITC
PDB ID for probe-target interaction (3D structure): --

DOI Reference: 10.1038/s41467-017-00954-1

In Cell Validations

In Vivo Data

No in Vivo Validations

SERP Reviews


15 Apr 2020
In Cell Rating

A negative control known as CMP-98 is available and should be used when testing the activity of CM-11.

15 Apr 2020
In Cell Rating
1 May 2020
In Cell Rating

CM11 is a potent and selective degrader of VHL that will induce auto-degradation of VHL in compatible cell lines. To distinguish inhibition versus degradation effects complenetary use of a VHL inhibitor such as VH 298 is recommended.