CM11 : Degrader (PROTAC) of VHL
Protein target names: VHL
Mechanism of action: Degrader (PROTAC)
In Vitro Validations
DOI Reference: 10.1038/s41467-017-00954-1
In Cell Validations
In Vivo Data
No in Vivo Validations
A negative control known as CMP-98 is available and should be used when testing the activity of CM-11.
CM11 is a potent and selective degrader of VHL that will induce auto-degradation of VHL in compatible cell lines. To distinguish inhibition versus degradation effects complenetary use of a VHL inhibitor such as VH 298 is recommended.