CM11

Degrader (PROTAC) of VHL

Structure

SERP Rating

In Cells

(3 ratings)

In Model Organisms

(0 ratings)

note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars.

Information

Protein target names: VHL

Mechanism of action: Degrader (PROTAC)

Recommended in-cell concentration:

10-500 nM

Primary References:

DOI - 10.1038/s41467-017-00954-1

Probe Availability:

In Vitro Validations

Uniprot ID: P40337

Target Class: Other post-translational modification

Target SubClass: E3 ubiquitin ligase

Potency: Kd

Potency Value: 10 nM

Potency Assay: ITC

PDB ID for probe-target interaction (3D structure): --

Target aliases:

von Hippel-Lindau disease tumor suppressor, VHL, V ...

DOI Reference: 10.1038/s41467-017-00954-1

In Cell Validations

In Vivo Data

No in Vivo Validations

I have extra information to add

SERP ratings and comments

SERP Ratings

In Cell Rating

SERP Comments:

A negative control known as CMP-98 is available and should be used when testing the activity of CM-11.

(last updated: 15 Apr 2020 )

SERP Ratings

In Cell Rating

(last updated: 15 Apr 2020 )

SERP Ratings

In Cell Rating

SERP Comments:

CM11 is a potent and selective degrader of VHL that will induce auto-degradation of VHL in compatible cell lines. To distinguish inhibition versus degradation effects complenetary use of a VHL inhibitor such as VH 298 is recommended.

(last updated: 1 May 2020 )