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CLM296 | CLM296 : Inhibitor of ALDH1A3
RATINGS:
Cellular Use: (1 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
ALDH1A3
    • IC50:2.1 nM
    up to 100 nM

    Selectivity

    In Cell Selectivity Assessment
    Potency Assay Off-Target:
    CLM296 had no effect on ALDH1A1-mediated Aldefluor fluorescence even at 100 μM in cell

    Potency
    Cellular
    In Vitro

    ALDH1A3

    Mode of Action: Inhibitor

    Structure-Activity-Relationship data available? No

    DOI Reference: 10.1016/j.isci.2026.114863

    In Vivo Validations

    Mouse
    Dose: 4 mg/Kg
    Route of delivery: Intraperitoneal
    Plasma half life: 8.62 h
    Systemic clearance: 39.8 mL/h/Kg
    Cmax: 24.24 uM
    Tmax: 1 h
    Area Under the Curve:: 233.4 uM*h/L
    Volume of Distribution at Steady-State: 494.4 mL/Kg

    DOI Reference: 10.1016/j.isci.2026.114863

    Dose: 4 mg/Kg
    Route of delivery: Oral
    Plasma half life: 12.9 h
    Systemic clearance: 72.2 mL/h/Kg
    Cmax: 10.97 uM
    Tmax: 4 h
    Area Under the Curve:: 128.5 uM*h/L
    Volume of Distribution at Steady-State: 1.35 L/Kg

    DOI Reference: 10.1016/j.isci.2026.114863

    Orthogonal Probes def

    MCI-INI-3

    Chemical Information

    Molecular Formula C29H22N2O2
    SMILEs CC(=O)c1ccc(-c2cc(-c3ccc(C(C)=O)cc3)c3nc(-c4ccccc4)cn3c2)cc1
    InChI InChI=1S/C29H22N2O2/c1-19(32)21-8-12-23(13-9-21)26-16-27(24-14-10-22(11-15-24)20(2)33)29-30-28(18-31(29)17-26)25-6-4-3-5-7-25/h3-18H,1-2H3
    Molecular weight 430.17 Da
    AlogP 6.740500000000006
    HBond acceptors 4
    HBond donors --
    Atoms 55

    References

    Publications

    Cross References

    canSAR: 7719209 canSAR: 12

    Expert Reviews

    by SERP
    (on 16 Apr 2026)
    Cellular Use Rating
    In Model Organisms
    The in vitro inhibitory activity and specificity of CLM296 was assessed for ALDH1A3 and ALDH1A1 (using cell lines that overexpress these enzymes), yet there are three ALDH1A subfamily isoforms - with ALDH1A2...
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