CCT374705

CCT374705 : Inhibitor of BCL6

Structure

SERP Rating

Probe CCT374705 is in the process of SERP review.

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Information

BCL6

Inhibitor

up to 1 µM

Probe Availability:

MedChemExpress

In Vitro Validations

Uniprot ID: P41182

Target Class: Transcription factor

Target SubClass: Transcriptional Repressor

Potency: IC50

Potency Value: 6 nM

Potency Assay: BCL6 TR-FRET

PDB ID for probe-target interaction (3D structure): 8C78

Target aliases:

B-cell lymphoma 6 protein, ZNF51, ZBTB27, LAZ3, BC ...

DOI Reference: 10.1021/acs.jmedchem.3c00155

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): Safety profiling of CCT374705 was carried out, and all targets (78) showed a Kd above 1 μM, although some targets (11/78) did show activity at concentrations below 10 μM. A kinase panel (468) confirmed selective activity and minimal off-target interactions.

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