BMS-986408

BMS-986408 : Inhibitor of DGKA, DGKZ

Structure

SERP Rating

Probe BMS-986408 is in the process of SERP review.

Please continue to check back for new reviews and commentary.

Information

DGKA
DGKZ

Inhibitor

up to 1 uM

In Vitro Validations

Uniprot ID: P23743

Target Class: Kinase

Target SubClass: Lipid kinase

Potency: IC50

Potency Value: 0.3 nM

Potency Assay: Biochemical lipid kinase assays

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Diacylglycerol kinase alpha, DAGK1, DAGK, DGKA, DG ...

DOI Reference: 10.1158/2326-6066.CIR-25-0156

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Potency assay (off target): Among the type I family, BMS-986408 showed > 100-fold selectivity for DGKα over DGKβ and DGKγ. Among the type IV family, BMS-986408 inhibited DGKζ and DGKι with similar potency. No significant activity was observed for Type II (DGKδ, DGKη, DGKκ), Type III (DGKε or Type V (DGKθ) family members.

I have extra information to add

SERP ratings and comments

No SERP comments found for BMS-986408