BMS-986235

BMS-986235 : Agonist of FPR2

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(2 ratings)

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Probe BMS-986235 is in the process of SERP review.

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Information

FPR2

Agonist

up to 100 nM
Reviewer recommended concentration: 100 nM to 1µM

Probe Availability:

MedChemExpress

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): Selective against FRP2 6800 fold

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SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

SERP Comments:

Based on the public information there is no outside family selectivity data. Therefore, the users might also want to consider this point in interpreting the experimental outcomes. The indicated doses are from in vivo PK studies; however, the Cmax values with the given doses look like just around EC50 or below estimated from in vitro studies. Because there is no in vivo safety/tox data available it is hard to justify the maximal doses to be used in animal studies, but probably 10 mg/kg would be worthwhile to test with careful animal safety observation such as behaviour.

(last updated: 4 Mar 2024 )

SERP Ratings

In Model Organisms

(last updated: 17 Mar 2024 )