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BIBR-1532 | BIBR-1532 : Allosteric of TERT
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (1 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
TERT
  • IC50:93 nM
  • IC50:200 nM
  • IC50:67 ± 14 nM
  • IC50:~1 μM
Allosteric
higher concentrations up to 50 µM may be required
up to 10 uM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
The selectivity profile for BIBR1532 was assessed in a panel of DNA and RNA polymerases. Enzymatic a ...

Potency
Cellular
In Vitro

TERT

Mode of Action: Allosteric

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1038/s41589-026-02238-6

Negative Control Compounds

BIBR1654
Notes: The structurally related molecule BIBR1654 serves as a negative control with IC50 (hTERT) = 5 µM.

Orthogonal Probes def

BRACO19

Chemical Information

Molecular Formula C21H17NO3
SMILEs C/C(=C\C(=O)Nc1ccccc1C(=O)O)c1ccc2ccccc2c1
InChI InChI=1S/C21H17NO3/c1-14(16-11-10-15-6-2-3-7-17(15)13-16)12-20(23)22-19-9-5-4-8-18(19)21(24)25/h2-13H,1H3,(H,22,23)(H,24,25)/b14-12+
Molecular weight 331.12 Da
AlogP 4.580000000000003
HBond acceptors 4
HBond donors 2
Atoms 42

Expert Reviews

by SERP
(on 23 Jun 2026)
Cellular Use Rating
Thus compound is recommended for use in human cell lines. It may not be used in standard model organisms such as rat or mouse. However, it may be used in these model organisms in xenograft studies.
by SERP
(on 15 Jul 2026)
Cellular Use Rating
In Model Organisms
(The reviewer did not leave any public comments)
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