BIBO3304

BIBO3304 : Antagonist of NPY1R

Structure

SERP Rating

In Cells

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In Model Organisms

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Probe BIBO3304 is in the process of SERP review.

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Information

NPY1R

Antagonist

up to 1 uM
Reviewer recommended concentration: 100 nM

Additional Data

SGC image SGC Chemical Probe Collection

Probe Availability:

TOCRIS

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): Selectivity within target family: BIBO3304 binds with more than 1,000-10,000-fold lower affinity to the other subtypes (Y2, Y4 and Y5). Outside target family: BIBO3304 was tested on 151 targets in a selectivity panel and showed ≥1,000-fold selectivity for 148 targets (≤50% inhibition @ 10 µM). In three assays (D2S(h), kappa KOP (h) and V1a (h)), the compound showed inhibition between 60-71%.

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SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

(last updated: 29 Dec 2022 )