BI 605906

Inhibitor of IKBKB

Structure

SERP Rating

Probe BI 605906 is in the process of SERP review.

Please continue to check back for new reviews and commentary.

Information

IKBKB

Inhibitor

5 uM

Additional Data

SGC image SGC Chemical Probe Collection

Probe Availability:

In Vitro Validations

Uniprot ID: O14920

Target Class: Kinase

Target SubClass: Serine kinase

Potency: IC50

Potency Value: 280 nM

Potency Assay: In vitro kinase assay at 0.100 mM ATP

PDB ID for probe-target interaction (3D structure): --

Target aliases:

, Inhibitor of nuclear factor kappa-B kinase subun ...

DOI Reference: 10.1042/BJ20101701

Uniprot ID: O14920

Target Class: Kinase

Target SubClass: Serine kinase

Potency: IC50

Potency Value: 49 nM

Potency Assay: Inhibition of IKKbeta

PDB ID for probe-target interaction (3D structure): --

Target aliases:

, Inhibitor of nuclear factor kappa-B kinase subun ...

DOI Reference: 10.1042/BJ20101701

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency end-point : Dmax

Probe Selectivity in Vitro:

Within targer family: 3 hits out of 397 kinases; Dose response measurements: GAK IC50 = 188 nM; AAK1 IC50 = 272 nM; IRAK3 IC50 = 921 nM; NanoBRET (SGC-FFM): GAK IC50 = 6.5 μM; AAK1 IC50 = 7.0 μM; IRAK3 IC50 > 20 μM. Outside target family: Panlabs panel: human PDE3A 31 % Ctrl at 10 µM; all other targets >50 % Ctrl

I have extra information to add

SERP ratings and comments

No SERP comments found for BI 605906