BI-1942

BI-1942 : Inhibitor of CMA1

Structure

SERP Rating

Probe BI-1942 is in the process of SERP review.

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Information

CMA1

Inhibitor

100 nM

Additional Data

SGC image SGC Chemical Probe Collection

In Vitro Validations

Uniprot ID: P23946

Target Class: Enzyme

Target SubClass: Peptidase

Potency: IC50

Potency Value: 0.4 nM

Potency Assay: Inhibition of recombinant human CMA1

PDB ID for probe-target interaction (3D structure): 3S0N

Target aliases:

Chymase, CYM, CYH, CMA1, CMA1_HUMAN, Mast cell pro ...

DOI Reference: 10.1021/jm400138z

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

Selectivity within target family: Eurofins protease panel (35 at 10 µM): Only off-target is CTSG (cathepsin G, IC50 = 110 nM, > 100-fold selective). Selectivity outside target family: Eurofins SafetyScreen (44) at 10 µM: clean.

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SERP ratings and comments

No SERP comments found for BI-1942