BAY2666605

BAY2666605 : Molecular Glue of PDE3A

Structure

Information

  • PDE3A
  • Molecular Glue
  • up to 1µM

In Vitro Validations

Uniprot ID: Q14432
Target Class: Enzyme
Target SubClass: Phosphodiesterase
Potency: IC50
Potency Value: 82 nM
Potency Assay: Biochemical assay
PDB ID for probe-target interaction (3D structure): --
Target aliases:
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A, ...

DOI Reference: 10.1021/acsmedchemlett.4c00336

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:
BAY-2666605 tested cleanly against panels of PDE enzymes, ion channels, (including hERG) and CYP isoforms and passed the Ames test.
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