BAY1125976
Allosteric Inhibitor of AKT2, AKT1
Structure
In Cells
In Model Organisms
Information
Protein target names: AKT2, AKT1
Mechanism of action: Allosteric Inhibitor
In Vitro Validations
DOI Reference: 10.1002/ijc.30457
In Cell Validations
In Vivo Data
SERP ratings and comments
SERP Ratings
Comments:
There are several inhibitors of this class, including Miransertib (ARQ092), MK2206, and Borussertib. Miransertib has some advantages with PK (particularly longer half-life: https://pubs.acs.org/doi/full/10.1021/acs.jmedchem.6b00619) and borussertib is a covalaent inhibitor and may offer some PD advantages depending on AKT1/2 turnover in a given cell type.
(last updated: 4 Nov 2020 )
SERP Ratings
(last updated: 12 Nov 2020 )
SERP Ratings
(last updated: 17 Nov 2020 )