BAY-899

BAY-899 : Allosteric Antagonist of LHCGR

Structure

SERP Rating

Probe BAY-899 is in the process of SERP review.

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Information

LHCGR

Allosteric

1 uM

Additional Data

SGC image SGC Chemical Probe Collection

Probe Availability:

MedChemExpress
MCULE

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

No activity on FSHR, TSHR. (hTSH antagonism IC50 = 24 µM; hFSH antagonism IC50 > 16 µM) Clean in commercial GPCR panel of 25 GPCRs (all < 70% inhibition / activation at 10μM compound concentration). Off-targets in the GPCR scan are SIGMAR1 (Ki = 1431.53 nM), TMEM97 (Ki = 2051.16 nM), OPRK1 (Ki = 7634.84 nM)Selectivity outside target family

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SERP ratings and comments

No SERP comments found for BAY-899