BAY-885
Inhibitor of MAPK7
Structure
In Cells
In Model Organisms
SERP ratings and comments
SERP Ratings
SERP Comments:
BAY-885 is an excellent inhibitor of ERK5. It is potent, selective against other kinases and bromodomain-containing proteins, and active in cells. There is not an inactive close analogue that is commercially available, so it could be useful to perform experiments of BAY-885 alongside the other commercially available ERK5 inhibitor, AX15836, for establishment of biology of ERK5’s kinase activity.
(last updated: 22 May 2020 )
SERP Ratings
SERP Comments:
1 uM is a reasonable maximum concentration to ensure ERK5 inhibition while not perturbing many other kinases. However, care should be taken in phenotypic assays to rule out inhibition of FER and ephrin kinases being responsible for observed phenotype at 1 uM.
(last updated: 4 Jul 2020 )
SERP Ratings
SERP Comments:
(last updated: 30 Jul 2020 )