BAY-474

BAY-474 : Inhibitor of MET

Structure

SERP Rating

Probe BAY-474 is in the process of SERP review.

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Information

Inhibitor

1-1000 nM

Additional Data

SGC image SGC Chemical Probe Collection

Probe Availability:

In Vitro Validations

Uniprot ID: P08581

Target Class: Kinase

Target SubClass: TK

Potency: IC50

Potency Value: <1 nM

Potency Assay: Biochemical MET assay

PDB ID for probe-target interaction (3D structure): --

Target aliases:

, Hepatocyte growth factor receptor, MET, MET_HUMA ...

DOI Reference: 10.7554/eLife.34311

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

Selectivity within target family: > 1000 fold vs all other kinases (Millipore panel (214 at 1 µM), IC50 > 10 µM) except for RPS6KA3 (RSK2) with IC50 = 0.9 µM. Selectivity outside target family: Eurofins-Panlabs radioligand binding assay (68) at 10 µM: clean. Clean GPCR scan.

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