BAY-3153

BAY-3153 : Antagonist of CCR1

Structure

SERP Rating

Probe BAY-3153 is in the process of SERP review.

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Information

CCR1

Antagonist

100 nM

Additional Data

SGC image SGC Chemical Probe Collection

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

Selectivity within target family: Inactive on CCR3 (human); IC50 > 30 µM for human CCR2, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCR10 and human CXCR1, CXCR2, CXCR3, CXCR4, CXCR5 Shows weak activity in the GPCR scan: The closest off-target is TMEM97 (Sigma2) (Ki = 1476.05 nM). Selectivity outside target family: Eurofins-Panlab results from close analog (O-cPr derivative) clean with closest off-targets @ 10 µM (% inhibition): MAOB (73 %), MLN (Motilin) (69 %).

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SERP ratings and comments

No SERP comments found for BAY-3153