BAY-179

BAY-179 : Inhibitor of Complex I

Structure

SERP Rating

Probe BAY-179 is in the process of SERP review.

Please continue to check back for new reviews and commentary.

Information

NDUFS2

Inhibitor

up to 1 uM

Additional Data

SGC image SGC Chemical Probe Collection

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

Selectivity within target family: Analog of BAY-179 shows selectivity against other complexes of the respiratory chain (Bio-chemical bovine OxPhos activity assay: > 30 µM for Complex 2, 3, 4 and 5).

Probe Selectivity in Cell:

On target cell activity for cell-based targets: Active in cellular mechanistic assay demonstrating cellular target engagement. Proliferation assays: IC50 = 79 nM (H1299 (human lung; Cellular ATP kit HTS)); IC50 = 33 nM (H1299 (human lung; CellTiter-Glo ATP));

I have extra information to add

SERP ratings and comments

No SERP comments found for BAY-179