AZD8055

AZD8055 : ATP competitive inhibitor of MTOR

Structure

SERP Rating

In Cells

(2 ratings)

In Model Organisms

(1 ratings)

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Probe AZD8055 is in the process of SERP review.

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Information

MTOR

ATP competitive

1 µM

Probe Availability:

MedChemExpress

In Vitro Validations

Uniprot ID: P42345

Target Class: Kinase

Target SubClass: PI3/PI4

Potency: IC50

Potency Value: 0.13 ± 0.05 nM

Potency Assay: Alpha-screen using truncated recombinant mTOR enzyme

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Serine/threonine-protein kinase mTOR, RAPT1, RAFT1 ...

DOI Reference: 10.1158/0008-5472.CAN-09-1751

Uniprot ID: P42345

Target Class: Kinase

Target SubClass: PI3/PI4

Potency: IC50

Potency Value: 0.8 ± 0.2 nM

Potency Assay: Alpha-Screen using native mTOR enzyme complexes extracted from HeLa cells.

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Serine/threonine-protein kinase mTOR, RAPT1, RAFT1 ...

DOI Reference: 10.1158/0008-5472.CAN-09-1751

Uniprot ID: P42345

Target Class: Kinase

Target SubClass: PI3/PI4

Potency: Ki

Potency Value: 1.3nM

Potency Assay: enzymatic assay using different ATP concentrations

PDB ID for probe-target interaction (3D structure): --

Target aliases:

Serine/threonine-protein kinase mTOR, RAPT1, RAFT1 ...

DOI Reference: 10.1158/0008-5472.CAN-09-1751

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Potency assay (off target): Within target family: AZD8055 showed excellent selectivity (∼1,000-fold) against all class I phosphatidylinositol 3-kinase (PI3K) isoforms and other members of the PI3K-like kinase family. Outside target family: AZD8055 has no significant activity against a panel of 260 kinases at concentrations up to 10 μM

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SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

(last updated: 12 May 2023 )

SERP Ratings

In Cell Rating

(last updated: 14 May 2023 )