Off target protein and potency:
KDR 24 nMFGFR4 165 nMIGFR 581 nMProbe Selectivity in Vitro:
selectivity was examined against a diverse panel of representative human kinases and AZD4547 shown to inhibit recombinant VEGFR2 (KDR) kinase, No enzyme inhibition was detected against ALK, CHK1, EGFR, MAPK1, MEK1, p70S6K, PDGFR, PKB, Src, Tie2, and PI3-kinase.
AXL >2,000, CDK2 >10,000, FAK >10,000, ROCK2 >50,000, AKT1 >100,000, ALK1 >100,000, p38 >100,000, PI3Ka >100,000
