AZD-5672

AZD-5672 : Antagonist of CCR5

Structure

SERP Rating

Probe AZD-5672 is in the process of SERP review.

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Information

CCR5

Antagonist

up to 100 nM

Probe Availability:

MedChemExpress

In Vitro Validations

Uniprot ID: P51681

Target Class: GPCR

Target SubClass: Chemokine receptor

Potency: IC50

Potency Value: 0.26 nM

Potency Assay: Radioligand displacement assay using CHO membranes

PDB ID for probe-target interaction (3D structure): --

Target aliases:

C-C chemokine receptor type 5, CMKBR5, CCR5_HUMAN, ...

DOI Reference: 10.1016/j.bmcl.2011.12.117

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

weak or no inhibition of the 5 major cytochrome P450 (CYP) isoforms, with IC50s for CYP1A1, CYP2C9, CYP2C19 > 50 µM; IC50 for CYP2D6 = 23 µM and IC50 for CYP3A4 = 9 µM

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SERP ratings and comments

No SERP comments found for AZD-5672