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Atorvastatin

Atorvastatin : Prodrug for HMGCR inhibitor

Structure

Information

  • HMGCR
  • Inhibitor, Prodrug
  • up to 20 uM

In Vitro Validations

Uniprot ID: P04035
Target Class: Lipid metabolism
Target SubClass: Sterol biosynthesis
Potency: IC50
Potency Value: 8 nM
Potency Assay: Inhibition of HMG-CoA Reductase , 6.2 nM (Ki, Rat homolog)
PDB ID for probe-target interaction (3D structure): 1HWK
Structure-activity relationship: yes
Target aliases:
3-hydroxy-3-methylglutaryl-coenzyme A reductase, H ...

DOI Reference: 10.1021/jm800001n

Uniprot ID: P04035
Target Class: Lipid metabolism
Target SubClass: Sterol biosynthesis
Potency: Ki
Potency Value: 6.2 nM
Potency Assay: Inhibition of HMG-CoA Reductase (Rat homolog)
PDB ID for probe-target interaction (3D structure): --
Target aliases:
3-hydroxy-3-methylglutaryl-coenzyme A reductase, H ...

DOI Reference: 10.1021/jm800001n

In Cell Validations

In Vivo Data

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SERP ratings and comments

No SERP comments found for Atorvastatin