ARCC-4

Degrader (PROTAC) of AR

Structure

SERP Rating

In Cells

(2 ratings)

In Model Organisms

(0 ratings)

note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars.

Probe ARCC-4 is in the process of SERP review.

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Information

Degrader (PROTAC)

> 50 nM

DOI - 10.1038/s42003-018-0105-8

Probe Availability:

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Probe Selectivity in Cell:

@ 1 uM ARCC-4 had no effect on glucocorticoid receptor and estrogen receptor levels, while there was a modest decrease in progesterone receptor (PR) A and B levels in T47D cells.

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SERP ratings and comments

SERP Ratings

In Cell Rating

(last updated: 9 Feb 2021 )

SERP+ Ratings

In Cell Rating

SERP+ Comments:

This is a good degrader, but some data are missing that should be presented to confirm the MoA. For example, knockdown of AR, or competition experiments should be provided. In particular, the lack of proteomics data is a bit concerning as it is a vital experiment for demonstrating off-target engagement. BAVDEGALUTAMIDE is a better characterised degrader.

(last updated: 6 Feb 2026 )