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AP-204 | AP-204 : Inhibitor of STK17B
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
STK17B
  • IC50:130 nM
  • IC50:350 nM
up to 10 µM
up to 1 uM

Selectivity

In Cell Selectivity Assessment
Potency Assay Off-Target:
Selective over STK17A in NanoBRET IC50 2200 nM
In Vitro Selectivity Assessment
Potency Assay Off-Target:
DiscoverX SCANmax at 1 uM provided S10 of 0.02, total number of kinases tested 403.

Potency
Cellular
In Vitro

STK17B

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

DOI Reference: 10.1182/blood.2025029950

In Vivo Validations

Mouse
Dose: 10 mg/Kg
Route of delivery: Oral
Plasma half life: 7.72 h
Systemic clearance: 221 mL/h/Kg
Cmax: 3.05 ug/mL
Tmax: 4.67 h
Area Under the Curve:: 47.17 ug/ml/h

DOI Reference: 10.1182/blood.2025029950

Orthogonal Probes def

SGC-STK17B-1

Chemical Information

Molecular Formula C15H9F3N2O3S2
SMILEs O=C(O)CSc1ncnc2cc(-c3ccc(OC(F)(F)F)cc3)sc12
InChI InChI=1S/C15H9F3N2O3S2/c16-15(17,18)23-9-3-1-8(2-4-9)11-5-10-13(25-11)14(20-7-19-10)24-6-12(21)22/h1-5,7H,6H2,(H,21,22)
Molecular weight 386.00 Da
AlogP 4.433600000000001
HBond acceptors 5
HBond donors 1
Atoms 34

References

Publications

Cross References

canSAR: CANSAR7719200

Expert Reviews

by SERP
(on 10 Feb 2026)
Cellular Use Rating
In Model Organisms
(The reviewer did not leave any public comments)
by SERP+
(on 27 May 2026)
Cellular Use Rating
In Model Organisms
In the manuscript the authors identified STK17B as novel molecular target to overcome the drug resistance in multiple myeloma. After the validation of STK17B molecular mechanism involved in the ferrotoptosis...
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