Chemical Probes logo
ALISERTIB | ALISERTIB : Inhibitor of AURKA
RATINGS:
Cellular Use: (0 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
Download

Probe Summary

More...

Targets Biochemical/Biophysical Potency Cellular Potency
AURKA
  • IC50:3.5 nM
  • IC50:1.2 nM
  • IC50:6.7 nM
up to 100 nM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
Alisertib has less activity against AURKB, with an IC50 value of 396.5 nM and showed selectivity in ...
In Cell Selectivity Assessment
Potency Assay Off-Target:
In HeLa cells, Alisertib is very selective against AURKB (IC50 = 1,534 nM)

Potency
Cellular
In Vitro

AURKA

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1021/cb100053q

In Vivo Validations

Mouse
Dose: 5, 10, 30 mg/Kg
Route of delivery: Oral
Target engagement assay: Alisertib treatment resulted in a dose-dependent TGI of 43.3%, 84.2%, and 94.7% for the 3, 10, and 30 mg/kg groups, respectively

DOI Reference: 10.1158/1078-0432.CCR-11-1536

Orthogonal Probes def

AMG-900
MK-5108

Chemical Information

Molecular Formula C27H20ClFN4O4
SMILEs COc1cc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2OC)=NC3)ccc1C(=O)O
InChI InChI=1S/C27H20ClFN4O4/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2/h3-11,13H,12H2,1-2H3,(H,34,35)(H,31,32,33)
Molecular weight 518.12 Da
AlogP 5.746100000000004
HBond acceptors 8
HBond donors 2
Atoms 57

Vendors

Note: This is not an exhaustive list and does not indicate endorsement by the Portal.

Expert Reviews

No SERP comments found for ALISERTIB

Probe ALISERTIB is in the process of SERP review.

Please continue to check back for new reviews and commentary.

If you would like to explore AI-generated evaluations, you may wish to visit the page for this compound on our collaborator website