ADL-5747

ADL-5747 : Agonist of OPRD1

Structure

SERP Rating

In Cells

(1 ratings)

In Model Organisms

(1 ratings)

note: The Chemical Probes Portal only endorses compounds as chemical probes for use as specific and selective modulators of the proposed target if they receive three or more (3-4) stars.

Probe ADL-5747 is in the process of SERP review.

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Information

OPRD1

Agonist

up to 10 uM

Probe Availability:

MCULE

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

Within Target family: Selective against mu (μ), kappa (κ) receptor Outside target family: Evaluated in vitro for the potential to inhibit four other major cardiac ion channels related to potassium, sodium, and calcium current generation [Ito(rKv4.3), hKvLQT1/h min K, hHNa, and ICa,L] showed relatively little inhibition of these ion channel currents at 100 uM. Not active against hERG and CYP2D6 (IC50s > 30uM)

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SERP ratings and comments

SERP Ratings

In Cell Rating

In Model Organisms

(last updated: 21 Oct 2022 )