ABT-724

Agonist of DRD4

Structure

SERP Rating

Probe ABT-724 is in the process of SERP review.

Please continue to check back for new reviews and commentary.

Information

DRD4

Agonist

10-10000 nM

Additional Data

SGC image SGC Chemical Probe Collection

Probe Availability:

In Vitro Validations

Uniprot ID: P21917

Target Class: GPCR

Target SubClass: Dopamine D4 receptors

Potency: Ki

Potency Value: 46.8 - 63.6 nM

Potency Assay: Radioligand-binding affinity for the dopamine receptor agonists using [3H]-A-369508 and membrane preparations expressing the human D4 variants (hDRD4.2: Ki=57.5 nM; hDRD4.4: Ki=63.6 nM; hDRD4.7: Ki= 46.8 nM)

PDB ID for probe-target interaction (3D structure): --

Target aliases:

D(4) dopamine receptor, DRD4, DRD4_HUMAN, Dopamine ...

DOI Reference: 10.1073/pnas.0308292101

In Cell Validations

In Vivo Data

Off-Target Selectivity Assesments

Probe Selectivity in Cell:

No activity up to 10 µM for hDRD2 Closest hit in CEREP panel at 10 µM: HTR1A with Ki=2780 nM (73% inhibition) (not confirmed in MSD) Selectivity outside target family: No activity in CEREP panel of other targets at 10 µM

I have extra information to add

SERP ratings and comments

No SERP comments found for ABT-724