ABBV-744
Inhibitor of BRD2, BRD4, BRD3, BRDT
Structure
In Cells
In Model Organisms
SERP ratings and comments
SERP Ratings
(last updated: 19 May 2020 )
SERP Ratings
SERP Comments:
ABBV-744 is an excellent chemical probe for studies on the second bromodomain (BD2) of BET bromodomain proteins. The inhibitor is based on the panBET bromodomain inhibitor ABBV-075 (mivebresib) which I suggest to be used in parallel to study BD2 versus pan BET bromodomain selective effects. Unfortunately, no negative control has been used / characterized in the article by Faivre et al (Nature 578, 306-310). I recommend therefore using other available BET inhibitors of different scaffold in parallel in cell based studies. ABBV-744 is suitable for in vivo use in mice.
(last updated: 4 Jun 2020 )
SERP Ratings
(last updated: 27 Oct 2020 )