A-366
A-366 : protein substrate competitive, SAM uncompetitive inhibitor of EHMT2 and EHMT1
Structure
In Cells
In Model Organisms
Information
Protein target names: EHMT2, EHMT1
Mechanism of action: protein substrate competitive inhibitor, SAM uncompetitive inhibitor
In Vitro Validations
DOI Reference: 10.1021/ml400496h
In Cell Validations
In Vivo Data
No in Vivo Validations
Reagent authentication certificate:
SERP ratings and comments
SERP Ratings
(last updated: 17 May 2016 )
SERP Ratings
SERP Comments:
Allow 3 days for effect: reduction of H3K9me2 in PC3 cells (IC50 = 100 nM). Use A-366 in parallel with UNC0642 (as an orthogonal control).
(last updated: 18 May 2016 )
SERP Ratings
SERP Comments:
A-366 is a cell active and selective probe that has fewer off target effects than UNC638.
(last updated: 30 May 2016 )