A-1596586

A-1596586 : Corrector of CFTR

Structure

SERP Rating

Probe A-1596586 is in the process of SERP review.

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Information

CFTR

Corrector

up to 1 uM

Additional Data

SGC image SGC Chemical Probe Collection

Probe Availability:

MedChemExpress

In Vitro Validations

No in Vitro Validations

In Cell Validations

In Vivo Data

No in Vivo Validations

Off-Target Selectivity Assesments

Probe Selectivity in Vitro:

Selectivity outside target family: Closest off targets at 10 µM are BZD peripheral (95.5 %), ADORA3 (63.9%) and ADRA2B (63.5%). Closest hits in the GPCR scan (43) are GABA/PBR (Ki = 19.59 nM), SIGMAR1 (Ki =314.63 nM) and TMEM97 (Ki =1192.34 nM).

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SERP ratings and comments

No SERP comments found for A-1596586