SGC707
Allosteric Inhibitor of PRMT3
Structure
In Cells
In Model Organisms
Information
Protein target names: PRMT3
Mechanism of action: Allosteric Inhibitor
In Vitro Validations
DOI Reference: 10.1002/anie.201412154
DOI Reference: 10.1002/anie.201412154
DOI Reference: 10.1002/anie.201412154
DOI Reference: 10.1002/anie.201412154
In Cell Validations
In Vivo Data
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SERP ratings and comments
SERP Ratings
(last updated: 10 Jun 2016 )
SERP Ratings
(last updated: 6 Sept 2016 )
SERP Ratings
(last updated: 25 Apr 2017 )
SERP Ratings
SERP Comments:
SGC707 displays excellent biochemical inhibition, with promising target selectivity. Cellular potency values were ranging and assay-dependent, but support use at 1-10 uM doses. The offset observed between biochemical and cellular potency should be further explored.
(last updated: 27 Apr 2017 )