RUSKI-41
Unsuitables - unsuitable to be used as a chemical probe
Structure
This is unsuitable as a chemical probe: While this
compound has been used to interrogate specific protein
targets, it is not a chemical probe and should not be used
in assays that depend on a potent and selective modulator
of the protein.
Non selective compound
Intended target: HHAT; RUSKI-41 inhibited reporter signal under Shh (and HHAT)-independent conditions, and RUSKI-43 is cytotoxic to Shh-Light2 cells, which do not depend on Shh signaling for their survival (EC50=21 uM).