JIB-04
Unsuitables - unsuitable to be used as a chemical probe
Structure
This is unsuitable as a chemical probe: While this
compound has been used to interrogate specific protein
targets, it is not a chemical probe and should not be used
in assays that depend on a potent and selective modulator
of the protein.
Non selective compound
Non selective compound, pan-active against multiple demethylases. Intended target: Jumonji protein demethylases. JIB-04 is a fragment that contains a promiscuous methylene hydrazine group. While chelation to metals by probes is okay depending on context, some degree of specificity is desired. JIB-04 lacks such specificity.