DZNep
Unsuitables - unsuitable to be used as a chemical probe
Structure
This is unsuitable as a chemical probe: While this
compound has been used to interrogate specific protein
targets, it is not a chemical probe and should not be used
in assays that depend on a potent and selective modulator
of the protein.
Non selective compound
This compound was initially reported as an inhibitor of SAH hydrolase and has been routinely applied at excessive concentrations as a catalytic EZH2 inhibitor. Arrowsmith et al., The promise and peril of chemical probes. Nat. Chem. Biol. 11, 536-41 (2015).