The Chemical Probes Portal SAB Conflict of Interest Policy

1. COI definition
This Policy applies to all SAB members considering any chemical probe in which their personal, professional, or financial interests (including through a Family Member or Affiliated Entity) may appear to be advanced either by their positive or negative recommendation, or whenever an SAB member’s personal or financial interests could be reasonably viewed as affecting his or her objectivity or independence in making recommendations to the Chemical Probes Portal.

In situations where an SAB member may create the appearance of advancing his/her own interests by making a recommendation about a chemical probe or having compromised objectivity with regard to that chemical probe, The Chemical Probes Portal requires that the SAB member:

  • Refrain from choosing to review the probe
  • Decline any assignment to review the chemical probe using the appropriate fields on the review form

(a) “Family Member” includes any spouse (including former spouses within last five years), sibling, child, grandchild, great-grandchild, or the spouse (or former spouse within five years) of such persons.

(b) “Affiliated Entity” includes an entity in which the Covered Person is an officer, director, trustee, employee, or has a more than 10% beneficial interest (directly or with one or more Family Members or other Affiliated Entities).

What are the most clear examples of SAB member COI?

An SAB member reviews a probe when he or she was an author or co-author on the initial publication(s) describing the probe.

Please note, authoring later publications describing research using the known probe would not be considered a COI according to this policy. Also, the authors and co-authors of the initial probe publication, while forbidden from reviewing a probe or commenting on its quality, are invited to provide comments about the proper use of a probe.

An SAB member reviews a probe when he or she has directly participated in a project focused on that probe that a reasonable person would consider a conflict of interest (i.e., by performing the review, the SAB member provides benefit to him/herself, the program or a company that employs the SAB member).

Please note, SAB members reviewing probes developed by their organization (Affiliated Entity) but without their direct participation would not be considered a COI according to this policy.


2. Disclosure and Decline to Review an assigned probe
When an SAB member is assigned a review that may constitute a COI, he or she must decline the review as the first response in the Recommendation/Review Form and submit that form so the probe can be reassigned. If there is a question as to whether a given situation constitutes a COI, the SAB member must use the available text field to document the potential COI for the portal.


3. Standard for Approval
If an SAB member discloses a potential COI, portal staff will determine whether a conflict exists, and portal staff reserve the right to consult with the Board of Directors or other SAB members to make this determination.


4. Administration of Policy
This Policy shall be administered by the Portal Staff along with advisors from our legal team and Board of Directors.

If you have any questions or comments about this Conflict of Interest Policy, please contact:

Susanne Muller-Knapp