C646
Unsuitables - unsuitable to be used as a chemical probe
Structure
This is unsuitable as a chemical probe: While this
compound has been used to interrogate specific protein
targets, it is not a chemical probe and should not be used
in assays that depend on a potent and selective modulator
of the protein.
Non selective compound
Cys reactive compound: Intended targets=E1A binding protein p300, CREB binding protein; Reacts with Cys-rich proteins including tubulins and inhibits tubulin polymerization; Shrimp et al., Characterizing the Covalent Targets of a Small Molecule Inhibitor of the Lysine Acetyltransferase P300. ACS Med Chem Lett. 7, 151-5 (2015).