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T-26c | T-26c : Inhibitor of MMP13
RATINGS:
Cellular Use: (2 reviews)

In Model Organisms: (2 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
References
Vendors
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Probe Summary

Targets Biochemical/Biophysical Potency Cellular Potency
MMP13
  • IC50:0.0069 nM
Inhibitor
10-100 nM

Selectivity

In Vitro Selectivity Assessment

Potency: IC50 - MMP2: 18 nM, MMP10: 160 nM, MMP3: 600 nM, MMP8: 780 nM

Potency Assay Off-Target:
MMP1, MMP7, MMP9, MMP14, TACE > 10,000 nM

Potency
Cellular
In Vitro

MMP13

Mode of Action: Inhibitor

Structure-Activity-Relationship data available? No

In Vivo Validations

Guinea pig (male)
Dose: 10 mg/kg (oral); 1 mg/kg (IV)
Route of delivery: Intravenous, Oral
Systemic clearance: 431 mL/h/kg (IV)

Reference: --

Negative Control Compounds

T-26f (5-((benzyl(methyl)amino)methyl)-N-(3-methoxybenzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-2-carboxamide)

Chemical Information

Molecular Formula C24H21N3O6S
SMILEs COc1cccc(CNC(=O)c2nc3scc(COCc4ccc(C(=O)O)cc4)c3c(=O)[nH]2)c1
InChI InChI=1S/C24H21N3O6S/c1-32-18-4-2-3-15(9-18)10-25-22(29)20-26-21(28)19-17(13-34-23(19)27-20)12-33-11-14-5-7-16(8-6-14)24(30)31/h2-9,13H,10-12H2,1H3,(H,25,29)(H,30,31)(H,26,27,28)
Molecular weight 479.12 Da
AlogP 0.0
HBond acceptors 9
HBond donors 3
Atoms 55

References

Publications

Cross References

canSARChEMBLBindingDBSGC Chemical Probes

Vendors

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Expert Reviews

by SERP
(on 15 May 2020)
Cellular Use Rating
In Model Organisms
(The reviewer did not leave any public comments)
by SERP
(on 19 May 2020)
Cellular Use Rating
In Model Organisms
(The reviewer did not leave any public comments)
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