Please let us know of any probes (or Historic Compounds) that should be included in The Chemical Probes Portal. We are interested in probes for a diverse range of protein targets. Portal staff will post probes for SAB review that meet the following criteria:
- The probe is published.
- The probe has been deposited into a suitable database, such as PubChem or ChEMBL.
- There are data to validate the prove is active against its intended target in a cellular and/or in vivo model system.
Simply fill out the form below, and portal staff will create a new probe record in our database and contact you or an appropriate point of contact to review and supplement the probe data set. Once the record is complete, we will post the probe for public view and review by our SAB. For more information about review, see The SAB Rating System.
We are also interested in identifying protein targets with no reliable probes available. Please let us know if a portal search for your protein of interest came up empty!
The form below can also be used for compounds that should not be used as probes. "Historic compounds" are small molecules that are typically non-selective or not sufficiently potent compared with other available chemical probes to merit the probe designation.
What happens after I suggest a probe?
1. If you are not an author who initially reported the probe, your suggestion will prompt us to contact the appropriate person to review and add to the probe record. Thank you!
2. If you are an author who initially reported the probe, we will contact you about reviewing the initial record so that your probe can be added to the Portal.