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STO609 | STO609 : ATP competitive inhibitor of CAMKK1, CAMKK2
RATINGS:
Cellular Use: (3 reviews)

In Model Organisms: (0 reviews)
Probe Summary
Selectivity
Potency
In Vivo
Control Compounds
Chemical Information
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Probe Summary

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Targets Biochemical/Biophysical Potency Cellular Potency
CAMKK1
  • Ki:250 nM
  • IC 50:380 nM
CAMKK2
  • Ki:47 nM
  • IC 50:120 nM
ATP competitive
Up to 300 nM

Selectivity

In Vitro Selectivity Assessment
Potency Assay Off-Target:
100-fold or more selective compared with CAMK1, CAMK4, CAMK2 gamma, MYLK, PRCK, and PRKACA
Selectivity Assessment Description:
STO-609 is highly selective for CaM-KK without any significant effect on the downstream CaM kinases ...

Potency
Cellular
In Vitro

CAMKK1

Mode of Action: ATP competitive

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1074/jbc.M201075200

CAMKK2

Mode of Action: ATP competitive

Structure-Activity-Relationship data available? Yes

DOI Reference: 10.1074/jbc.M201075200

Chemical Information

Molecular Formula C19H10N2O3
SMILEs O=C(O)c1ccc2c3c1cccc3c(=O)n1c3ccccc3nc21
InChI InChI=1S/C19H10N2O3/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18/h1-9H,(H,23,24)
Molecular weight 314.07 Da
AlogP 3.2901000000000016
HBond acceptors 5
HBond donors 1
Atoms 34

References

Publications

Cross References

Expert Reviews

by SERP
(on 29 Aug 2016)
Cellular Use Rating
(The reviewer did not leave any public comments)
by SERP
(on 29 Aug 2016)
Cellular Use Rating
(The reviewer did not leave any public comments)
by SERP
(on 29 Aug 2016)
Cellular Use Rating
(The reviewer did not leave any public comments)
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