News

August 13, 2016

We are pleased to announce the publication of chemical probes that target proteins in Protein methyltransferase (PMT) family. Today we released validation data for the probes listed below:

UNC0642

BIX-01294

CPI-169

CPI-360

July 29, 2016

We are pleased to announce the publication of chemical probes that target proteins in the PARP family. Today we released validation data for the probes listed below.These probes are still under review by our SAB so it will take a few weeks for ratings and recommendations to emerge. Stay tuned, as we will be releasing more probes as well as inviting new submissions over the coming weeks and months! You can submit your published probe or suggest we add a probe anytime here.

July 11, 2016

We are currently looking to expand the Portal's database to include inhibitors and chemical probes that target proteins in the Protein methyltransferase (PMT) family. If you have generated and published or published follow-on validation data for chemical probes that are active against PMT proteins please submit your probes to the portal.

For your probe submissions to be considered in our next Batch, please complete the submission by July 18, 2016.

July 11, 2016

We are looking to expand the Portal's database to include inhibitors and chemical probes that target proteins in the PARP family. If you have generated and published or published follow-on validation data for chemical probes that are active against PARP family proteins please submit your probes to the portal.

For your probe submissions to be considered in our next Batch, please complete the submission by July 18, 2016.

June 30, 2016

Our new site is now live! Please visit the portal and look around. In addition to the site’s new look, we’ve added new content, including a lot more data about the existing probes, reviewer ratings and their comments. We hope that you will find the site friendly and helpful to use.

June 27, 2016

Since high-throughput chemical screens have moved into the mainstream of science, medicinal chemists have noted that certain compounds or compound classes repeatedly arise as hits in these assays. Unfortunately, these hits arise repeatedly not because they are versatile and exciting chemical scaffolds but because they are promiscuous entities, which react non-specifically with biomolecules or interfere with assay components rather than directly and specifically affecting the protein target of interest.

June 21, 2016

By monitoring the interaction between a chemical probe and its protein target in a model system, a researcher gains confidence that the resulting phenotypic changes can be attributed to the probe’s activity against that protein. Assays that allow a researcher to detect and ideally to quantify the protein-chemical probe binding interaction are referred to as target-engagement assays and are considered an essential part of the evidence required to properly validate a probe for use in a biological system.

June 17, 2016

The Portal will employ an expert peer-review process to vet and rate chemical probes. Key to this process is the Portal’s Scientific Advisory Board (SAB) comprising experts in medicinal chemistry, pharmacology and chemical biology representing a global community and multiple professional environments (e.g., pharma, biotech, clinical centers or academia).

June 14, 2016

On Jun 30, 2016, we are relaunching The Chemical Probes Portal. The new site will feature a new user interface, new navigation, a robust database with in cell and/or in vivo validation data for the ~100 existing probes on the portal, as well as expert recommendations for selecting and applying these probes according to best practices.

June 13, 2016

The Chemical Probes Portal proudly announces its founding Board of Directors: Mark Bunnage (Pfizer), Aled Edwards (SGC), Yung Lie (Damon-Runyon Cancer Research Foundation), Herbert Waldmann (Max Planck Institute of Molecular Physiology), Tim Willson (SGC UNC), and Paul Workman (ICR).

Pages