Introducing Historic Compounds

The Portal now features a new class of compounds called Historic Compounds. These small molecules are typically non-selective or not sufficiently potent compared with other available chemical probes to merit the probe designation.

A table of all Historic Compounds currently posted to the portal is found here.  To recommend we add a historic compound - use our probe submission form.

In the Portal, historic compounds can be readily distinguished from chemical probes: they are catalogued without much of the detailed validation information that accompanies a probe, they do not include an image and they are not rated by our SAB. To ensure there is no confusion, each historic compound is also designated by a generic and specific note to clarify the categorization. The generic note simply indicates that it is a historic compound; the specific note provides some context for why it is considered a historic compound. For an example, please visit the staurosporine page.

We opted for the category title “Historic Compound” to avoid giving our users the impression that these compounds cannot be valuable reagents. While we do not recommend that scientists use these compounds as chemical probes (that is, as selective and potent inhibitors of specific protein targets), we recognize that when applied as non-specific reagents, these compounds may still be valuable tools.

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