JQ1

Protein target name: 
BRD2, BRD3, BRD4, BRDT
Mechanism of action: 
Competitive inhibitor

Primary Reference

SAB Comments

This is an excellent selective cellular probe for the BET family of bromodomains, binding potently to all eight (BD1 and BD2 of BRD2/3/4/T). It has been extensively used in cells as a positive control. Its drawback is its suboptimal in vivo pharmacokinetics (IV t1/2 0.9 hours: source http://dx.doi.org/10.1038%2Fnature09504), so for in vivo studies, I would recommend using other BET-family bromodomain inhibitors.

JQ1 is very potent probe for the BET family of proteins that can be used in cells.